Quick-term menopausal hormone remedy (MHT) didn’t have long-term cognitive results when given to girls in early postmenopause, in accordance with a research printed November 21st within the open-access journal PLOS Medication by Carey Gleason from the College of Wisconsin-Madison, USA, and colleagues.
Whereas MHT can supply aid from the difficult signs of menopause, many ladies and docs are hesitant to start out MHT resulting from security considerations. Earlier analysis has linked one type of hormone remedy to gentle cognitive impairment and dementia in girls older than 65 years of age, prompting analysis on the significance of age and timing of remedy on cognitive impairment. Different research have instructed that transdermal estrogen might have long-term cognitive advantages.
Within the Kronos Early Estrogen Prevention Examine (KEEPS), girls in early postmenopause with good cardiovascular well being have been randomized to obtain one in every of two sorts of MHT (oral or transdermal estrogen) or placebo. On the finish of 4 years, no cognitive profit or hurt was seen in those that acquired MHT in comparison with the placebo group. Nevertheless, long-term cognitive results of MHT are nonetheless understudied.
On this new follow-up study-;the KEEPS Continuation Examine-;researchers revisited contributors almost ten years later to repeat a collection of cognitive checks. Amongst 275 girls, though MTH failed to guard towards cognitive decline, short-term MHT additionally had no long-term damaging cognitive affect.
These findings might supply reassurance to girls contemplating MHT whereas including to the rising physique of analysis supporting the significance of timing for MHT. Extra analysis is required to research whether or not these outcomes are generalizable to girls with greater cardiovascular threat.
The authors add, “For girls in menopause and the well being care suppliers caring for them, getting direct, clear and evidence-based details about menopausal hormone remedy is difficult. And so they want knowledge to information their selections.”
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Journal reference:
Gleason, C. E., et al. (2024). Lengthy-term cognitive results of menopausal hormone remedy: Findings from the KEEPS Continuation Examine. PLOS Medication. doi.org/10.1371/journal.pmed.1004435.