Researchers from POSTECH and Kyungpook Nationwide College have developed a novel inhalable therapeutic supply system for lung most cancers, leveraging mucoadhesive protein nanoparticles impressed by the adhesive properties of marine mussels. This effort was spearheaded by Professor Hyung Joon Cha (Division of Chemical Engineering and Graduate Faculty of Convergence Science and Expertise with a specialization in Medical Science) and Dr. Yeonsu Jeong (Division of Chemical Engineering) at POSTECH, in collaboration with Professor Yun Kee Jo (Division of Biomedical Convergence Science and Expertise, Superior Institute of Science and Expertise) at Kyungpook Nationwide College.
Lung most cancers stays one of many deadliest cancers globally. Non-small cell lung most cancers (NSCLC), which accounts for 85% of all lung most cancers circumstances, is especially difficult to deal with because of difficulties in early detection. Present anticancer remedies are predominantly administered intravenously, impacting each malignant and wholesome tissues, typically resulting in extreme hostile results. Because of this, inhalable therapeutics have emerged as a promising different, enabling localized drug supply on to the lungs. Nonetheless, the efficacy of this strategy has been considerably hindered by the lung’s mucosal limitations and immune cells. Constructing on this context, collaborative analysis has culminated within the improvement of a mucoadhesive protein nanoparticle designed for lung most cancers remedy.
This strategy leverages the exceptional adhesive properties of marine mussel proteins, famend for his or her underwater adhesion. Drawing inspiration from the oxidation-reduction mechanisms of foot protein kind 6 (fp-6), the researchers engineered foot protein kind 1 (fp-1) by integrating cysteine, making a biomaterial with enhanced adhesive power and exact drug supply capabilities inside the lung most cancers microenvironment. These nanoparticles exhibit distinctive therapeutic efficacy by enabling selective payload launch whereas successfully inhibiting launch in wholesome tissues to attenuate hostile results. Furthermore, the intrinsic biocompatibility, biodegradability, and immunocompatibility of marine mussel proteins guarantee superior organic security and considerably lengthen the retention of anticancer medicine, thereby amplifying their therapeutic influence.
In animal fashions of lung most cancers, the nanoparticles developed by the analysis group and their contained anti-cancer medicine confirmed effectiveness in inhibiting most cancers cell metastasis and invasion after being delivered to the lungs by way of a nebulizer and adhering to the mucosa for prolonged intervals. This development holds the potential to boost affected person entry to lung most cancers remedy, because the simplified inhalation-based drug administration may very well be self-managed at dwelling. Moreover, this strategy might considerably enhance sufferers’ high quality of life by decreasing the necessity for hospital visits.
The findings from our examine have the potential to considerably improve each the precision and efficacy of lung most cancers remedies, whereas considerably bettering sufferers’ high quality of life.”
Hyung Joon Cha, Professor , Pohang College of Science & Expertise
The analysis findings have been revealed on-line in Biomaterials, the premier worldwide journal for biomaterial analysis. This examine was made attainable by way of funding from the Nationwide Analysis Basis (NRF) Mid-Profession Researcher Program, the Ministry of Well being and Welfare’s Dental and Medical Expertise R&D Program, and the Pan-Governmental Regenerative Medication Expertise Growth Program.
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Journal reference:
Jeong, Y., et al. (2024) Redox-activatable inhalable mucoadhesive proteinic nanotherapeutics for focused remedy of lung most cancers. Biomaterials. doi.org/10.1016/j.biomaterials.2024.123004.
