Ladies that suffer from endometriosis have an elevated danger of untimely and early menopause, each naturally and surgically, College of Queensland researchers have discovered.
A complete worldwide research discovered girls with endometriosis are at 7 instances the chance of surgical menopause (involving the removing of each ovaries) and face a better danger of untimely menopause (earlier than age 40) or early menopause (between ages 40-44).
Dr. Hsin-Fang Chung, from UQ’s Faculty of Public Well being, stated whereas it was identified that endometriosis and its therapy can scale back egg high quality and amount, analysis on its impact on the timing of menopause was restricted.
We discovered surgical menopause occurred, on common,19 months earlier in girls with endometriosis, whereas pure menopause occurred 5 months earlier.
Ladies with endometriosis are twice as more likely to expertise surgical menopause beneath the age of 40, or 1.4 instances extra more likely to have pure menopause earlier than 40.”
Dr. Hsin-Fang Chung, UQ’s Faculty of Public Well being
Senior writer, Professor Gita Mishra, stated it was already identified early and surgical menopause have been associated to adversarial outcomes akin to heart problems and untimely loss of life.
“Stopping or managing early or medically induced menopause requires a complete understanding of its underlying causes and proactive measures to deal with the long-term well being dangers related to it,” Professor Mishra stated.
The research – which analysed knowledge from practically 280,000 girls in Australia, the UK, Sweden and Japan between 1996 and 2022 – is the most important to look at the sort and timing of menopause in girls with endometriosis.
The analysis is a part of InterLACE, a global collaboration analyzing girls’s reproductive well being and power illness throughout their lifetime.
Endometriosis is a power and infrequently debilitating inflammatory illness, affecting 1 in 7 Australian girls, the place tissue much like the liner of the womb grows in different components of the physique.
Dr. Chung stated she hoped the proof would inform updates to endometriosis administration tips, emphasising the significance of long-term monitoring of the situation.
“Ladies with endometriosis ought to be conscious that they could be at elevated danger of early or induced menopause, go to their GP often to examine for power illness danger elements, and deal with prevention methods,” she stated.
Dr. Chung’s subsequent step is to analysis the influence of endometriosis on long-term power illness dangers.
The findings might be offered on the sixteenth World Congress on Endometriosis in Sydney later this month.
The analysis is printed in Human Copy.
Supply:
Journal reference:
Chung, H.-F., et al. (2025). Affiliation between endometriosis and sort and age of menopause: a pooled evaluation of 279 948 girls from 5 cohort research. Human Copy. doi.org/10.1093/humrep/deaf068.
