Utilizing a high-pressure water jet to function on an enlarged prostate can higher protect the flexibility to ejaculate, in contrast with commonplace laser surgical procedure, finds analysis.
The method has comparable outcomes to laser surgical procedure and could be carried out with robotic help, so may scale back ready occasions for males with urinary issues brought on by an enlarged prostate.
Preliminary findings of the WATER III trial are offered in the present day [Saturday 22 March] on the 2025 European Affiliation of Urology (EAU) Congress in Madrid.
The WATER III trial concerned a water-based surgical process, referred to as Aquablation, at present used for small- and medium-sized prostates. The trial assessed its security and effectiveness to be used with giant prostates, in contrast with surgical procedure utilizing lasers. It additionally investigated opposed unintended effects resembling erectile dysfunction and urinary incontinence.
The trial was led by researchers from the College of Bonn and concerned sufferers throughout Germany and the UK.
An enlarged prostate, generally known as Benign Prostatic Hyperplasia (BPH), is the most typical prostate situation in older males. The prevalence of BPH will increase with age, affecting over 50% of males aged over 50 and rising to greater than 80% in these aged over 70, with world and regional variations influenced by inhabitants getting older and prostate quantity variations. Whereas non-cancerous, it will possibly trigger urinary issues and considerably impression males’s well being.
Because the prostate gland grows, BPH can squeeze the urethra resulting in a frequent must urinate, a weak urine stream, and leaking or dribbling of urine. The place life-style modifications or remedy should not efficient, males can go for surgical procedure. Mostly, this entails utilizing a wire loop or laser to interrupt up and take away the surplus prostate tissue to open up the urethra.
Retrograde ejaculation is a typical aspect impact of BPH surgical procedure. That is the place semen is ejaculated into the bladder, reasonably than by way of the penis. Whereas not a well being danger, retrograde ejaculation can compromise sexual enjoyment and fertility.
Aquablation is a minimally invasive surgical process that makes use of a high-pressure water jet, underneath robotic steerage and ultrasound imaging, to find and destroy extra prostate tissue. Commonplace laser surgical procedure for BPH contains Holmium laser prostate surgical procedure (HoLEP) and Thulium laser enucleation of the prostate (ThuLEP), which break up or vaporise extra prostate tissue.
Within the trial, the researchers recruited 202 males who required surgical procedure for his or her BPH. The boys all had giant prostates (between 80 – 180 mL). Simply over half (98) of sufferers had been assigned to bear aquablation remedy, with the rest (88) assigned to bear both HoLEP or ThuLEP laser surgical procedure.
Throughout a three-month follow-up, males had been assessed for retrograde ejaculation, incontinence and the severity of their decrease urinary tract signs, utilizing the Worldwide Prostate Symptom Rating.
Of the 89 males within the trial who had been sexually energetic, retrograde ejaculation was skilled by simply 15% of males within the aquablation group in contrast with over three-quarters of males (77%) within the laser surgical procedure group. Urinary incontinence was reported in 9% of the lads within the aquablation group in contrast with 20% in the usual therapy group. Brief-term symptom enchancment and opposed occasions had been comparable throughout each teams.
Our research exhibits important promise for aquablation remedy as an alternative choice to laser-based therapies for males with bigger prostates with BPH. Many males settle for their signs as a traditional a part of ageing, however after surgical procedure, these sufferers are very glad to eliminate their remedy and signs. Proof that additionally it is efficient at preserving ejaculatory perform brings added advantages for many who want to protect their intercourse lives.”
Professor Manuel Ritter, Lead Researcher, Head of Urology on the College Hospital Bonn, Germany
He continues: “The training curve for surgeons to carry out laser surgical procedure is steep, so the flexibility to supply aquablation to males even with bigger prostates will make therapies extra accessible.”
There are a number of surgical approaches for BPH. The commonest possibility, transurethral resection of the prostate (TURP), makes use of a heated wire loop to shave away extra prostate tissue. A earlier five-year trial has proven aquablation can considerably scale back the chance of retrograde ejaculation as a aspect impact in contrast with TURP.
Commenting on the trial, Professor Cosimo De Nunzio, Affiliate Professor of Urology at Sapienza College of Rome, Italy, and Member of the EAU Scientific Congress Workplace, stated:
“Irregular ejaculation is a really frequent complication following BPH surgical procedure, and so the problem we now have is to strike a steadiness between treating the signs and preserving ejaculation perform. Retrograde ejaculation is a selected concern for males who would like to see little to no impression on their intercourse lives following therapy. So, for this group of males, the outcomes of this research present that aquablation is a really promising possibility.
“Nevertheless, the follow-up interval of three months could be very brief and future analysis would wish to incorporate sufferers with power urinary retention or urethral catheters, who usually require therapy for BPH. Longer-term research would additionally want to incorporate different essential measures, like a discount in prostate-specific antigen within the blood, or an improved urine stream fee.”
The trial was funded by aquablation remedy developer PROCEPT BioRobotics ® and the sponsor is the College of Bonn.
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