
The Federated European Genome-phenome Archive (FEGA) is remodeling how delicate human genomic information is shared and accessed. Constructing on the longstanding European Genome-phenome Archive (EGA)—a database for human genetic, phenotypic, and medical information—FEGA allows researchers to securely uncover and analyze human genomic information whereas guaranteeing compliance with nationwide and worldwide information safety laws.
By decentralizing information storage throughout nationwide nodes, FEGA ensures information stays safe inside its nation of origin whereas additionally being accessible to researchers worldwide.
FEGA’s paper has been printed in Nature Genetics.
From centralization to federation
Within the final twenty years, as the amount of human genomic datasets grew bigger and authorized necessities to entry the information have been tightened, it turned clear {that a} single repository just like the EGA may not meet the worldwide neighborhood’s wants. The EGA crew proposed adopting a federated mannequin, according to native authorized and moral frameworks, whereas additionally permitting entry to those information globally.
What’s a federated mannequin?
A federated mannequin is a distributed community through which a number of entities function beneath a typical framework. Every node or entity retains management over its personal information and processes, whereas agreed-upon requirements and protocols enable them to collaborate and share information globally. This method allows safe and coordinated information sharing throughout completely different nations, guaranteeing that native authorized and moral necessities are met.
EMBL-EBI and the Middle for Genomic Regulation (CRG) in Spain have co-managed the EGA since 2008. Collectively, they helped form the federated data-sharing mannequin now utilized by FEGA.
Two main tasks additionally helped make FEGA’s federated mannequin potential. The ELIXIR-EXCELERATE initiative—a program supporting worldwide information sharing—helped lay the early groundwork with proof-of-concept research. ELIXIR-CONVERGE— a mission to standardize information administration throughout Europe—has accelerated the event of the primary nationwide FEGA nodes.
“Within the early days of establishing FEGA, we have been grappling with the restrictions of a centralized system. It felt like we have been dealing with huge challenges,” mentioned Mallory Freeberg, Human Genomics Group Chief at EMBL-EBI.
“Via collaboration, we overcame these obstacles to construct the foundations of FEGA. I am immensely proud to have been a part of this endeavor. It is an thrilling time for this community, and there may be a lot extra to attain as we proceed pushing the boundaries.”
By 2020, the muse for FEGA’s federated mannequin was set, resulting in the official launch of the useful resource in September 2022. The primary collaboration agreements have been signed by nodes in Sweden, Norway, Finland, Germany, and Spain.
Impression via international collaboration
“International well being challenges like pandemics and uncommon ailments don’t respect nationwide borders,” mentioned Arcadi Navarro, ICREA Analysis Professor on the Universitat Pompeu Fabra and Director of the EGA crew on the Middle for Genomic Regulation.
“By increasing past Europe and including the Canadian node, we consolidate the Federated EGA because the world’s most complete, safe, and numerous useful resource for genomic and well being information to sort out these pressing questions.”
The first datasets have been submitted to FEGA by late 2023, proving the federated mannequin in apply. These information have since continued to develop, with FEGA now holding almost 40 datasets.
The community has additionally expanded with nodes in Portugal and Poland becoming a member of in 2023, and Canada in December 2024. Discussions are additionally ongoing with many different collaborators, together with a Swiss node who’re at the moment “Observers’ of FEGA.
“This milestone partnership offers Canadian researchers with a swift, safe connection to international collaborators, fostering scientific and medical innovation whereas persevering with to uphold our dedication to privateness and compliance,” mentioned Steven Jones, lead for the CGA node and Co-Director of Canada’s Michael Smith Middle for Genome Sciences at BC Most cancers.
FEGA goals to assist international analysis in illness prognosis and customized remedy. The next are a couple of examples.
A federated future
Trying forward, FEGA may also proceed to refine its metadata requirements, together with these developed as a part of the International Alliance for Genomics and Well being (GA4GH), to extend information discoverability and interoperability. It will assist future integration of multi-omics datasets, in addition to medical well being data for a extra full image of illness biology.
Efforts to assist extra information submissions are additionally underway, together with the event of coaching supplies and the institution of FEGA node-specific assist desks to help native customers. Federated analytics are additionally within the works, which is able to allow safe, multi-node analyses with out the necessity to obtain delicate information.
As FEGA evolves, it units a excessive customary for international human genomics information sharing. By integrating multi-omics and medical information, FEGA will assist analysis in direction of improved customized medication and assist inform public well being methods to finally enhance affected person outcomes.
Extra info:
Teresa D’Altri et al, The Federated European Genome–Phenome Archive as a worldwide community for sharing human genomics information, Nature Genetics (2025). DOI: 10.1038/s41588-025-02101-9
Quotation:
A federated future to assist genomic medication (2025, March 7)
retrieved 7 March 2025
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