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It is true! The brand new drug for migraine Aimovig is lastly right here. The very first GCRP treatment designed to stop migraines. It’s been years within the making with very optimistic leads to the research. However there’s another factor to pay attention to, and I needed to discover this bit out from my very own private expertise. It is referred to as the put up advertising and marketing information.
However earlier than we get to that, listed below are some particulars that can assist you think about if this new and really costly remedy is for you.
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My first tip is to debate together with your physician how this treatment compares to what you’ve got already tried. You may want to leap by some hoops – that means you’ll have to have a failed checklist of different drugs earlier than you possibly can trial this one.
You may have to see a Neurologist or specialist, and you will have to suit the standards.
Now… let us take a look at the dosage and a few professionals and cons of this new drug for migraine Aimovig.
Aimovig for MigrainePhotograph: Amgen
Aimovig Dosage
- Through injection pen referred to as an “auto injector”
You may want 2 injections and never only one… as prescribed by your physician. [1]
Each prefilled autoinjector and prefilled syringe are single-dose and ship all the contents. [3]
The Execs and Cons of This New Drug for Migraine Aimovig
Execs
Minimal unwanted side effects reported (thus far).
Very optimistic leads to the scientific trials and research. 40% of contributors acquired a 50% discount (or higher).
It’s useful for episodic and persistent migraine.
No warnings or contraindications. [3]
Good absorption. It has absolute bioavailability: 82% [3]
Cons
Hostile results from 1 – 10%: [3]
- Injection website ache (5-6%)
- Cramps, muscle spasms (<1 to three%)
Unknown dangers throughout being pregnant.
The value tag! Presently $575 per injection = $6,900 per 12 months.
When you’re delicate to drugs, or have a response – it may take time to recuperate. It stays in your physique for a month – half-life: 28 days. [3]
“The needle defend throughout the white cap of the prefilled autoinjector and grey needle cap of the prefilled syringe include dry pure rubber (a by-product of latex), which can trigger allergic reactions in people delicate to latex.” [3]
This new drug is just not a cure-all however it may assist if you cannot take a triptan or different migraine meds.
“Elizabeth Loder, a neurologist at Harvard, identified in a tweet {that a} situation of the FDA approving Aimovig was that the corporate has to review whether or not individuals who take the drug are extra in danger for liver toxicity, coronary heart assaults, and stroke.” [2]
So there’s nonetheless extra information to be gathered for this new drug.
In three research each the people receiving the drug and the placebo had reductions in migraine days. BUT, and that is vital: “40 p.c of the migraine sufferers within the trials acquired an enormous discount in migraine days—50 p.c or higher. When you’re a kind of individuals, nice! And for those who’re one of many 24 p.c who had the identical discount within the placebo group, hey, I’m comfortable for you too.” [2]
This new drug for migraine Aimovig could not forestall all of your assaults. But when they cut back your assaults by half or a 3rd… this can nonetheless be a big enchancment.
It’s simply the value tag you’ll have to justify.
A Warning About The Put up Advertising and marketing Knowledge
I discovered about this the laborious manner final November after being hospitalized from a life threatening response to the shingles treatment Famciclovir (Famvir).
Right here’s what the put up advertising and marketing information exhibits for Famvir (2018) that utilized to my analysis of ITP – Idiopathic Thrombocytopenia, below blood and lymphatic system problems.
That is the info gathered AFTER the scientific trials and AFTER the FDA approval and AFTER it’s launched to {the marketplace}.
It’s what occurs after… within the basic inhabitants of tens of millions that take the drug! For me, this was an enormous shock and even as soon as my physician and I found the trigger, there was no manner for me to submit documentation to these authorities in an effort to replace the postmarketing information including me as one other uncommon statistic.
That is one thing to pay attention to. They should add it in for authorized causes, however you want absolute proof your response was from that drug.
So with this in my latest expertise pool of knowledge, I’d wait one other 12 months to see what occurs with this new drug for migraine Aimovig earlier than experimenting.
When you’re already taking it and also you need to add some professionals and cons, contact me right here and I will add them.
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MIGRAINE MEDICATIONS Associated Articles
How one can be extra migraine savvy proper now…
New Drug For Migraine Aimovig Sources:
1. Cottrill, J. (2018) Large Information: First CGRP Inhibitor for migraine Permitted in US – Aimovig. Accessible [online] at: http://headacheandmigrainenews.com/big-news-first-cgrp-inhibitor-approved-in-us-aimovig/
2. Skwarecki, B. (2018) The New Drug for Migraines Has Some Drawbacks. Accessible [online] at: https://vitals.lifehacker.com/the-new-drug-for-migraines-has-some-drawbacks-1826201295?IR=T
3. Medscape (2018) Erenumab (Rx) Hostile Results. Accessible [online] at: https://reference.medscape.com/drug/aimovig-erenumab-1000205#4