A examine on donor lungs preserved exterior the physique earlier than transplantation demonstrated that the hypothermic oxygenated machine perfusion (HOPE) approach is a protected and efficient lung preservation technique, even with whole out-of-body instances approaching 20 hours.
Jitte Jennekens, MSc, organ perfusionist/transplant coordinator on the UMC Utrecht within the Netherlands, introduced the examine outcomes at as we speak’s Annual Assembly and Scientific Classes of the Worldwide Society of Coronary heart and Lung Transplantation (ISHLT) in Boston.
“This method is getting used to protect donor livers and kidneys and is being studied in medical trials for hearts, nevertheless it hasn’t gotten that a lot consideration for lung preservation but,” stated Jennekens.
Ex vivo lung perfusion (EVLP) is a way that enables for donor lungs to be maintained, assessed, and probably reconditioned exterior of the physique earlier than transplantation. The lungs are related to a pump and a ventilator and perfused with an answer that features as a physiological fluid.
The UMC Utrecht developed its HOPE protocol to securely prolong perfusion instances, to keep up the viability of the lungs in a single day till the transplantation may be carried out in the course of the day.
Donor lungs chosen for EVLP are usually transported on ice after which warmed to 37 levels Celsius utilizing a normothermic EVLP (referred to as nEVLP) protocol for practical evaluation. Following nEVLP, the lungs are then returned to ice till the transplant begins.
The HOPE protocol eliminates the second interval on ice by assessing the lungs throughout one hour of nEVLP after which preserving the lungs at 12 levels C till the process.
Jennekens introduced knowledge evaluating the outcomes of 12 instances performed utilizing the nEVLP-HOPE protocol with a historic cohort of donor lungs transplanted instantly into sufferers with out ex vivo lung perfusion.
The management cohort included 118 instances of lungs transplanted instantly with out perfusion between 2017 and 2022. The instances have been carried out between 2022 and 2024 utilizing the HOPE protocol for logistical causes.
No lungs within the nEVLP-HOPE group have been rejected for transplantation, and short-term outcomes have been comparable between the examine and management teams.
“Our findings point out that HOPE is a protected and efficient lung preservation technique after a interval of normothermic EVLP,” Jennekens stated.
Jennekens stated the subsequent step is to find out the preservation technique that can be most useful to a particular kind of donor lung.
“Extending perfusion instances for donor lungs exterior of the physique will permit for a future by which donor lungs may be optimized with completely different therapies,” she stated.
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Donor lungs safely preserved as much as 20 hours out-of-body previous to transplantation (2025, April 27)
retrieved 27 April 2025
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